Txao – Pterostilbene
Unlocking the Power of Pterostilbene: A Comprehensive Guide
While pterostilbene is naturally found in plants like berries, grapes, and nuts, it is most abundant in blueberries. However, the actual content in these sources is relatively minuscule, requiring an impractical amount of nearly 100 kilos of blueberries daily to experience significant benefits. Txao is formulated with Pterostilbene that is derived from the bark of the Indian Kino Tree which serves as a potent polyphenol with exceptional bioavailability.
Pterostilbene, a nutrient from the same family as resveratrol, has been garnering significant attention from scientists and health enthusiasts alike. What makes pterostilbene stand out are its remarkable health benefits, particularly its potent antioxidant and anti-inflammatory properties.
Health Benefits of Pterostilbene
Pterostilbene, offers a wide array of health benefits that make it a valuable addition to any wellness routine. Its antioxidant and anti-inflammatory properties help to combat oxidative stress and reduce the risk of chronic diseases. Pterostilbene helps support cardiovascular health, improve cognitive function, and boosts overall immune system function. As a key ingredient in Txao, it plays a vital role in promoting your health and longevity.
Anti-inflammatory with Anti-Aging Protection
There’s evidence that pterostilbene has anti-inflammatory properties, reduces oxidative stress and reduces production of reactive oxygen species, which contribute to many chronic diseases. It exerts its anti-inflammatory effects through several pathways. It inhibits the production of pro-inflammatory cytokines and enzymes, such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), which are involved in the inflammatory response. Additionally, pterostilbene modulates nuclear factor-kappa B (NF-κB) signaling, a key regulator of inflammation, by suppressing its activation and translocation to the cell nucleus.
Cardiovascular and Metabolic Support
A gut-microbiota-dependent metabolite of L-carnitine, trimethylamine-N-oxide (TMAO), has been recently discovered as an independent and dose-dependent risk factor for cardiovascular disease (CVD). Carnitine is found in our diets which is likely one of the cause of vascular inflammation leading to cardiovascular diseases. The study above found that pterostilbene is able to reduce TMAO formation and decrease vascular inflammation in carnitine-fed mice. Research also suggests that pterostilbene may help reduce blood pressure and improve cholesterol levels, offering protection against cardiovascular issues and metabolic syndrome.
Cancer Prevention
Pterostilbene has demonstrated promising potential in preventing cancer tumor growth by modulating cell cycle progression, gene expression related to cancer pathways and inducing apoptosis (programmed cell death).
Greater than 95% of breast malignancies are of epithelial origin; the induction of epithelial-to-mesenchymal transition (EMT) has been shown to initiate the metastatic process in breast carcinoma. Pterostilbene modulates the EMT process in breast cancer cells both in vitro and in vivo with demonstration of anti-metastatic potential as shown in the two figures above.
Neurological and Cognitive Health
Pterostilbene’s antioxidant properties extend to neurological protection, potentially aiding in memory retention, reducing cognitive decline, and protecting against neurological diseases like Alzheimer’s.
Pterostilbene vs. Resveratrol
While structurally similar to resveratrol and sharing many benefits, pterostilbene demonstrated better anti-inflammatory capabilities. That is why Txao is formulated with pterostilbene to deliver optimal health benefits.
Bioavailability and Cellular Uptake
Unlike its cousin resveratrol, pterostilbene boasts superior bioavailability, being many times more easily absorbed by the body and transported into cells. Studies have shown that it has two to four times better cellular uptake than resveratrol, remaining present in the body for longer durations, thus intensifying its benefits.
Science for your Health
Pterostilbene, pronounced terro-still-bene, is a promising dietary compound found in antioxidant-rich foods. Its diverse range of benefits, from fighting oxidative stress to supporting cardiovascular health and potentially preventing cancer, positions it as a valuable addition to one’s wellness regimen. As research continues to unveil its full potential, pterostilbene stands as a beacon of hope in the quest for holistic health and longevity.
Click here to enjoy the benefits of Pterostilbene found in Txao
References
Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Molecules. 2022 Sep 25;27(19):6316.
Choo Q.-Y., Yeo S.C.M., Ho P.C., Tanaka Y., Lin H.-S. Pterostilbene Surpassed Resveratrol for Anti-Inflammatory Application: Potency Consideration and Pharmacokinetics Perspective. J. Funct. Foods. 2014;11:352–362.
Su CM, Lee WH, Wu AT, Lin YK, Wang LS, Wu CH, Yeh CT. Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition. J Nutr Biochem. 2015 Jun;26(6):675-85.
Cox FF, Misiou A, Vierkant A, Ale-Agha N, Grandoch M, Haendeler J, Altschmied J. Protective Effects of Curcumin in Cardiovascular Diseases-Impact on Oxidative Stress and Mitochondria. Cells. 2022 Jan 20;11(3):342.
Benameur T, Giacomucci G, Panaro MA, Ruggiero M, Trotta T, Monda V, Pizzolorusso I, Lofrumento DD, Porro C, Messina G. New Promising Therapeutic Avenues of Curcumin in Brain Diseases. Molecules. 2021 Dec 31;27(1):236.
McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482.
Koh YC, Li S, Chen PY, Wu JC, Kalyanam N, Ho CT, Pan MH. Prevention of Vascular Inflammation by Pterostilbene via Trimethylamine-N-Oxide Reduction and Mechanism of Microbiota Regulation. Mol Nutr Food Res. 2019 Oct;63(20):e1900514.