Have you ever wondered why more people around you seem to be living with autoimmune diseases?

Could environmental changes and modern lifestyle factors be contributing to this trend?

Could a natural supplement offer a way to support the body’s antioxidant defenses?

To explore these questions, we need to understand the relationship between inflammation and oxidative stress, and the research behind the ingredients in Txao.

Are We Seeing More Autoimmune Diseases?

Have you noticed that autoimmune diseases seem to be receiving more attention today?

You’re not imagining it.

Autoimmune conditions have been on a significant rise.

Studies show that their prevalence has been increasing.

In fact, in developed nations, it’s estimated that around 1 in 10 to 1 in 20 people may be living with an autoimmune condition.

Environmental changes, modern diets, and lifestyle factors are being studied as a trigger.

Greater awareness and improvements in diagnosis may also contribute to the number of cases identified.

However, it is clear: autoimmune diseases are becoming more common.

Understanding Autoimmune Diseases

Have you ever wondered how your immune system, designed to protect you, can turn against your own body?

Autoimmune diseases occur when immune responses mistakenly target the body’s own healthy tissues.

This leads to inflammation and tissue damage.

Why this happens is complex.

What Factors May Contribute to Autoimmune Diseases?

Several factors are being investigated for their potential roles in autoimmune disease development.

Environmental exposures: Pollutants, chemicals and infections are among the factors researchers have studied. Their effects vary, and researchers continue to investigate how different exposures may influence immune function.

Diet and lifestyle: Diet quality, physical activity and sleep can influence general health and aspects of inflammatory biology. We are still learning about their roles in autoimmune diseases.

Gut health: The gut microbiome interacts with the immune system. Changes in the composition of gut microorganisms may be associated with immune regulation and certain autoimmune conditions.

The hygiene hypothesis: This hypothesis proposes that changes in early-life exposure to microorganisms may influence immune development.

The Role of Inflammation

Inflammation is part of the body’s normal defense and repair processes.

In autoimmune diseases, inflammatory activity can persist.

If left unchecked, it can lead to more serious issues.

Another important area of research is oxidative stress.

The body naturally produces reactive oxygen species (ROS) during normal cellular activity.

However, oxidative stress can occur when reactive molecules place excessive demands on the body’s antioxidant defenses.

Inflammation and oxidative stress are interconnected.

Inflammatory activity can increase the production of reactive molecules, while oxidative processes can influence inflammatory signaling.

This relationship provides the biological context for the Txao Internal Balance System.

The Txao Internal Balance System

The relationship between oxidative stress and inflammatory pathways is an important part of the thinking behind Txao’s formulation.

The Internal Balance System is built around two connected areas of biology.

01 — Oxidative Balance

Antioxidant defenses help the body manage reactive molecules generated through normal cellular activity and other biological processes.

02 — Inflammatory Balance

Together, these two areas form the biological framework behind Txao.

Rather than focusing on individual ingredients alone, the Internal Balance System connects their roles within one considered formulation.

Learn more about Internal Balance System →

Curcumin: The Anti-Inflammatory Powerhouse

Curcumin is a principal bioactive compound found in turmeric (Curcuma longa). It has attracted considerable scientific interest because of its antioxidant properties and its effects on inflammatory signaling pathways.

Research suggests that curcumin can influence molecules and cellular pathways involved in inflammatory responses. Studies have also examined its relationship with oxidative stress.

A 2022 systematic review and meta-analysis by Zeng and colleagues examined 31 randomized controlled trials involving curcumin or Curcuma longa extracts across 10 types of autoimmune disease. The review reported encouraging findings in some conditions, including rheumatoid arthritis, psoriasis and ulcerative colitis.

The researchers discussed possible mechanisms involving regulatory T cells (Tregs) and inflammatory markers, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), TNF-α, TGF-β1 and IL-6.

A 2019 review by Yang and colleagues examined research into curcumin in autoimmune and rheumatic diseases. They found that curcumin supplementation emerges as an effective therapeutic agent with minimal-to-no side effects, which can be added in conjunction to current
standard of care.

Pterostilbene: Enhanced Anti-oxidant Support

Pterostilbene is a naturally occurring polyphenol related to resveratrol. Researchers have investigated its antioxidant properties and its effects on inflammatory and immune-related processes.

A 2013 study by Perecko and colleagues investigated pterostilbene’s effects on neutrophil activity in an experimental model of arthritis. The study indicates that the promising effects of pterostilbene on reactive oxygen species operate by different mechanisms. These findings provide insight into pterostilbene’s potential interactions with inflammatory processes

A 2020 study by Yashiro and colleagues investigated pterostilbene’s effects on dendritic cells and regulatory T-cell development. The researchers reported changes in immune-cell activity in laboratory experiments and reduced colonic inflammation.

This review highlights pterostilbene’s antioxidant activity and potential anti-inflammatory effects, which may help modulate oxidative stress and inflammation associated with various disease processes.