Txao: Unlocking the Power of Pterostilbene
Unlocking the Power of Pterostilbene through Silbinol®
While pterostilbene is naturally found in plants like berries, grapes, and nuts, it is most abundant in blueberries. However, the actual content in these sources is relatively minuscule, requiring an impractical amount of nearly 100 kilos of blueberries daily to experience significant benefits.
Txao is formulated with Silbinol®, a patented, standardized extract of Pterocarpus marsupium (Indian Kino Tree) — one of nature’s richest sources of pterostilbene. Unlike generic extracts, Silbinol® ensures consistent potency, purity, and superior absorption, allowing your body to fully harness pterostilbene’s antioxidant and anti-inflammatory potential.
Pterostilbene, a nutrient from the same family as resveratrol, has been garnering significant attention from scientists and health enthusiasts alike. What makes pterostilbene — and Silbinol® in particular — stand out are their remarkable bioavailability, stability, and clinically supported health benefits.
Health Benefits of Pterostilbene
Pterostilbene offers a wide array of health benefits that make it a valuable addition to any wellness routine. Its antioxidant and anti-inflammatory properties help combat oxidative stress and reduce the risk of chronic diseases. It supports cardiovascular health, enhances cognitive function, and boosts immune resilience.
These benefits have been most consistently observed with standardized forms such as Silbinol®, used in Txao, ensuring higher consistency, purity, and bioavailability across studies. As a key ingredient in Txao, Silbinol® plays a vital role in promoting your health and longevity — naturally and effectively.
Anti-inflammatory with Anti-Aging Protection
There’s evidence that pterostilbene has powerful anti-inflammatory properties, reducing oxidative stress and the production of reactive oxygen species, which contribute to chronic disease and aging. It exerts these effects through several key pathways:
- Inhibiting pro-inflammatory cytokines and enzymes such as COX-2 and iNOS.
- Modulating NF-κB signaling, a key regulator of inflammation, by suppressing its activation and translocation to the cell nucleus.
In human trials using Silbinol®, participants showed increases in antioxidant markers (like higher glutathione) along with reductions in certain inflammatory indicators — supporting its role in immune balance and healthier aging. Animal studies have further confirmed Silbinol® lowers pro-inflammatory genes (e.g. TNF-α, VCAM-1) and oxidative stress in vascular tissue.
Cardiovascular and Metabolic Support
A gut-microbiota-dependent metabolite of L-carnitine, trimethylamine-N-oxide (TMAO), has been discovered as a major risk factor for cardiovascular disease (CVD). Carnitine, found in red meat and certain foods, can increase vascular inflammation.
Research shows that pterostilbene can reduce TMAO formation and decrease vascular inflammation in carnitine-fed mice. Additional studies suggest it helps regulate blood pressure and cholesterol levels, offering protection against cardiovascular issues and metabolic syndrome.
These vascular and metabolic effects are consistent with findings on Silbinol®, which demonstrated improvements in lipid profiles and endothelial function — key to maintaining a strong heart and healthy circulation.
Cancer Prevention
Pterostilbene has demonstrated promising potential in preventing cancer tumor growth by modulating cell cycle progression, gene expression, and inducing apoptosis (programmed cell death).
More than 95% of breast malignancies are of epithelial origin; the induction of epithelial-to-mesenchymal transition (EMT) is a key step in metastasis. Pterostilbene modulates EMT in breast cancer cells, showing clear anti-metastatic potential both in vitro and in vivo (as shown in the two figures above).
Many of these findings are based on standardized pterostilbene sources such as Silbinol®, ensuring consistency and clinical reliability in antioxidant and cancer prevention research.
As demonstrated above, pterostilbene — and by extension, Silbinol® — combats cancer through multiple mechanisms of action, strengthening the body’s natural defense against abnormal cell growth.
Neurological and Cognitive Health
Pterostilbene’s ability to penetrate the blood-brain barrier amplifies its neuroprotective potential. It supports neuronal signaling, synaptic plasticity, and mitochondrial function — all essential for memory and cognition.
It can activate signaling pathways that protect the brain from oxidative stress and inflammation, allowing the nervous system to preserve homeostasis and resist age-related decline.
Because Silbinol®’s pterostilbene is highly lipophilic, it crosses the blood-brain barrier more efficiently, ensuring sustained protection for brain cells and promoting long-term cognitive clarity.
Pterostilbene vs. Resveratrol
While structurally similar to resveratrol and sharing many benefits, pterostilbene has superior anti-inflammatory and antioxidant capabilities. It remains longer in the body, with significantly higher bioavailability.
This advantage is further amplified in Silbinol®, where optimized molecular structure and purity translate into greater systemic retention and cellular antioxidant defense — making it a superior nutraceutical for long-term vitality.
Bioavailability and Cellular Uptake
Unlike its cousin resveratrol, pterostilbene boasts superior bioavailability, being two to four times more easily absorbed and retained in cells.
Txao’s formulation with Silbinol® takes this a step further — ensuring consistent potency, higher absorption, and longer-lasting presence in the body. This means more of what you take actually reaches your cells, where it can fight oxidative stress and inflammation effectively.
Science for your Health
Pterostilbene (pronounced terro-still-been) is a promising dietary compound found in antioxidant-rich foods. Its ability to fight oxidative stress, support cardiovascular and brain health, and potentially prevent cancer makes it one of the most valuable nutraceuticals for healthy aging.
Through its inclusion of Silbinol®, Txao ensures that every dose delivers clinically validated, bioavailable pterostilbene — bridging ancient botanical wisdom with modern science. This synergy helps your body stay strong, balanced, and resilient against oxidative and immune-related challenges.
Click here to experience the benefits of Silbinol® — powered by Txao.
References
Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Molecules. 2022 Sep 25;27(19):6316.
Choo Q.-Y., Yeo S.C.M., Ho P.C., Tanaka Y., Lin H.-S. Pterostilbene Surpassed Resveratrol for Anti-Inflammatory Application: Potency Consideration and Pharmacokinetics Perspective. J. Funct. Foods. 2014;11:352–362.
Majeed M, Nagabhushanam K, Paulose S, Mundkur L. A Short-Term Safety Evaluation of Silbinol®– an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study. J Evid Based Integr Med. 2023 Jan-Dec;28:2515690X231198312.
Su CM, Lee WH, Wu AT, Lin YK, Wang LS, Wu CH, Yeh CT. Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition. J Nutr Biochem. 2015 Jun;26(6):675-85.
Obrador E, Salvador-Palmer R, Jihad-Jebbar A, López-Blanch R, Dellinger TH, Dellinger RW, Estrela JM. Pterostilbene in Cancer Therapy. Antioxidants (Basel). 2021 Mar 21;10(3):492.
Cox FF, Misiou A, Vierkant A, Ale-Agha N, Grandoch M, Haendeler J, Altschmied J. Protective Effects of Curcumin in Cardiovascular Diseases-Impact on Oxidative Stress and Mitochondria. Cells. 2022 Jan 20;11(3):342.
Benameur T, Giacomucci G, Panaro MA, Ruggiero M, Trotta T, Monda V, Pizzolorusso I, Lofrumento DD, Porro C, Messina G. New Promising Therapeutic Avenues of Curcumin in Brain Diseases. Molecules. 2021 Dec 31;27(1):236.
Dutta BJ, Rakshe PS, Maurya N, Chib S, Singh S. Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline. Ageing Res Rev. 2023 Dec;92:102125. doi: 10.1016/j.arr.2023.102125.
McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482.
Koh YC, Li S, Chen PY, Wu JC, Kalyanam N, Ho CT, Pan MH. Prevention of Vascular Inflammation by Pterostilbene via Trimethylamine-N-Oxide Reduction and Mechanism of Microbiota Regulation. Mol Nutr Food Res. 2019 Oct;63(20):e1900514.